Описание
Инструкция по применению
Принимать по две капсулы два раза в день или по назначению врача.
! Перед использованием проконсультируйтесь со своим лечащим врачом. Если Вы принимаете варфарин или другие лекарства обязательно проконсультируйтесь с врачом о возможной совместимости. Не использовать если упаковка была повреждена.
Состав
120 капсул в упаковке
Размер порции: 2 капсулы | Количество на порцию | % Дневная норма |
---|---|---|
Глюкозамиан сульфат (в виде глюкозамина сульфат хлорид натрия) | 750 mg | ** |
Хондроитин сульфат (в виде хондроитин сульфат натрия) (CS BiO-ACTIVE®) | 600 mg | ** |
Метилсульфонилметан (МСМ) | 500 mg | ** |
** Суточная доза не определена.
Все формулы XYMOGEN® соответствуют стандартам качества GMP.
Не содержит
Пшеницы, клейковины, кукурузы, дрожжи, сои, молочных продуктов, рыбы, арахиса, лесных орехов, яиц, ингредиентов, полученных из генетически модифицированных организмов (ГМО), искусственных красителей, искусственных сахарозаменителей или искусственных консервантов.
Содержит
Ракообразные (креветки и краба).
Другие ингредиенты
ГПМЦ (капсула), аскорбилпальмитат, масло среднецепочечных триглицеридов и диоксид кремния.
Условия хранения
Хранить закрытым в прохладном, сухом месте, недоступном для детей.
Список литературы
- Kahan A, Uebelhart D, De Vathaire F, et al. Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2009 Feb;60(2):524- 33. [PMID: 19180484]
- Möller I, Pérez M, Monfort J, et al. Effectiveness of chondroitin sulphate in patients with concomitant knee osteoarthritis and psoriasis: a randomized, double-blind, placebocontrolled study. Osteoarthritis Cartilage. 2010 Jun;18 Suppl 1:S32-40. [PMID: 20399899]
- Wildi LM, Raynauld JP, Martel-Pelletier J, et al. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI. Ann Rheum Dis. 2011 Jun;70(6):982-89. [PMID: 21367761]
- Hochberg MC, Clegg DO. Potential effects of chondroitin sulfate on joint swelling: a GAIT report. Osteoarthritis Cartilage. 2008;16 Suppl 3:S22-24. [PMID: 18768335]
- Monfort J, Pujot J, Contreras-Rodriguez O, et al. Effects of chondroitin sulfate on brain response to painful stimulation in knee osteoarthritis patients. Ann Rheum Dis. 2014;73:82. doi:10.1136/annrheumdis-2014-eular.4908.
- Adebowale A, Du J, Liang Z, et al. The bioavailability and pharmacokinetics of glucosamine hydrochloride and low molecular weight chondroitin sulfate after single and multiple doses to beagle dogs. Biopharm Drug Dispos. 2002 Sep;23(6):217-25. [PMID: 12214321]
- Tat SK, Pelletier JP, Mineau F, et al. Variable effects of 3 different chondroitin sulfate compounds on human osteoarthritic cartilage/chondrocytes: relevance of purity and production process. J Rheumatol. 2010 Mar;37(3):656-64. [PMID: 20110528]
- Barnhill JG, Fye CL, Williams W, et al. Chondroitin product selection for the glucosamine/ chondroitin arthritis intervention trial. J Am Pharm Assoc. 2006 Jan-Feb;46(1):14-24. [PMID: 16529337]
- Pelletier JP, Raynauld JP, and Beaulieu A, et al. In a two-year double-blind randomized controlled multicenter study, chondroitin sulfate was significantly superior to celecoxib at reducing cartilage loss with similar efficacy at reducing disease symptoms in knee osteoarthritis patients [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). http:// acrabstracts.org/abstract/in-a-two-year-double-blind-randomized-controlled-multicenterstudy-chondroitin-sulfate-was-significantly-superior-to-celecoxib-at-reducing-cartilageloss-with-similar-efficacy-at-reducing-disease-sym/. Accessed January 8, 2016.
- Singh JA, Noorbaloochi S, MacDonald R, et al. Chondroitin for osteoarthritis. Cochrane Database Syst Rev. 2015 Jan 28;1:CD005614. [PMID: 25629804]
- Glucosamine. Natural Medicines. https://naturalmedicines.therapeuticresearch.com/ databases/food,-herbs-supplements/professional.aspx?productid=807. Accessed January 13. 2016.
- Kelly GS. The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. Altern Med Rev. 1998 Feb;3(1):27-39. Review. [PMID: 9600024]
- Igarashi M, Kaga I, Takamori Y, et al. Effects of glucosamine derivatives and uronic acids on the production of glycosaminoglycans by human synovial cells and chondrocytes. Int J Mol Med. 2011 Jun;27(6):821-27. [PMID: 21455564]
- Kapoor M, Mineau F, Fahmi H, et al. Glucosamine sulfate reduces prostaglandin E(2) production in osteoarthritic chondrocytes through inhibition of microsomal PGE synthase-1. J Rheumatol. 2012 Mar;39(3):635-44. [PMID: 22089456]
- Largo R, Alvarez-Soria MA, Díez-Ortego I, et al. Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes. Osteoarthritis Cartilage. 2003 Apr;11(4):290-98. [PMID: 12681956]
- Selvan T, Rajiah K, Nainar MS, et al. A clinical study on glucosamine sulfate versus combination of glucosamine sulfate and NSAIDs in mild to moderate knee osteoarthritis. Scientific World Journal. 2012;2012:902676. [PMID: 22577354]
- Tat SK, Pelletier JP, Vergés J, et al. Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study. Arthritis Res Ther. 2007;9(6):R117. [PMID: 17996099]
- Lippiello L, Woodward J, Karpman R, et al. In vivo chondroprotection and metabolic synergy of glucosamine and chondroitin sulfate. Clin Orthop Relat Res. 2000 Dec;(381):229-40. [PMID: 11127660]
- Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006 Feb 23;354(8):795-808. [PMID: 16495392]
- Fransen M, Agaliotis M, Nairn L, et al. Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens. Ann Rheum Dis. 2015 May;74(5):851-58. [PMID: 24395557]
- Hochberg MC, Martel-Pelletier J, Monfort J, et al. Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, noninferiority trial versus celecoxib. Ann Rheum Dis. 2016 Jan;75(1):37-44. [PMID: 25589511]
- Methylsulfonylmethane (MSM). Monograph. Altern Med Rev. 2003 Nov;8(4):438-41. [PMID: 14653770]
- Usha PR, Naidu MU. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clin Drug Investig. 2004;24(6):353-63. [PMID: 17516722]
- Brien S, Prescott P, Lewith G. Meta-analysis of the related nutritional supplements dimethyl sulfoxide and methylsulfonylmethane in the treatment of osteoarthritis of the knee. Evid Based Complement Alternat Med. 2011;2011:528403. [PMID: 19474240]
- Kalman DS, Feldman S, Scheinberg AR, et al. Influence of methylsulfonylmethane on markers of exercise recovery and performance in healthy men: a pilot study. J Int Soc Sports Nutr. 2012 Sep 27;9(1):46. [PMID: 23013531]
- Barmaki S, Bohlooli S, Khoshkhahesh F, et al. Effect of methylsulfonylmethane supplementation on exercise — Induced muscle damage and total antioxidant capacity. J Sports Med Phys Fitness. 2012 Apr;52(2):170-74. [PMID: 22525653]
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